Eslicarbazepine: new adjunctive treatment for partial epilepsy
نویسندگان
چکیده
منابع مشابه
A Review of Eslicarbazepine Acetate for the Adjunctive Treatment of Partial-Onset Epilepsy
Eslicarbazepine acetate (ESL) is a novel antiepileptic drug indicated for the treatment of partial-onset seizures. Structurally, it belongs to the dibenzazepine family and is closely related to carbamazepine and oxcarbazepine. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL is a pro-drug that is rapidly metabolized almost exclusively into S-licarbazepine, the b...
متن کاملUpdate on treatment of partial onset epilepsy: role of eslicarbazepine
Partial epilepsy comprises simple partial seizures, complex partial seizures, and secondarily generalized seizures, and covers more than 60% of patients with epilepsy. Antiepileptic drugs are generally considered to be the major therapeutic intervention for epilepsy but, despite a broad range of commonly used antiepileptic drugs, approximately 30% of adult patients and approximately 25% of chil...
متن کاملRole of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures
Eslicarbazepine is a new dibenzazepine antiepileptic agent. It is a high affinity antagonist of the voltage-gated sodium channel. It is closely related to both carbamazepine and oxcarbazepine. Eslicarbazepine has similar affinity to inactivated sodium channels (channels in just activated neurons) as carbamazepine, and greater efficacy in animal models of seizure than oxcarbazepine. In human pla...
متن کاملUpdate on the role of eslicarbazepine acetate in the treatment of partial-onset epilepsy
Eslicarbazepine acetate (ESL) is a once daily new third generation antiepileptic drug that shares the basic chemical structure of carbamazepine and oxcarbazepine - a dibenzazepine nucleus with the 5-carboxamide substituent, but is structurally different at the 10,11-position. ESL is a pro-drug metabolized to its major active metabolite eslicarbazepine. Despite the fact that the exact mechanism ...
متن کاملSevere myoclonic epilepsy of infancy: Seizure reduction during adjunctive eslicarbazepine in two cases☆
The aim of this study was to preliminarily determine, in a short open study, the effectiveness of eslicarbazepine acetate (ESL) in two patients with severe myoclonic epilepsy of infancy (SMEI).We report on a 17-year-old Italian boy and a 21-year-old Italian girl with SMEI and a severe clinical outcome, in whom we identified two mutations (5053del AA fs1685X1691 and 931G > T E311X) in the alpha ...
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ژورنال
عنوان ژورنال: Prescriber
سال: 2010
ISSN: 0959-6682,1931-2253
DOI: 10.1002/psb.600